Two new norneolignans from Callicarpa kwangtungensis. Issue 2 (17th January 2020)

• Record Type: Journal Article
• Authors: Bi, Hong-Yu; Xu, Chun-Liang; Fu, Hui-Zheng; Zhou, Zhi-Qiang; Zhong, Rui-Jian; Dai, Mian; Wang, Dong
• Is Part Of: Natural product research. Volume 34:Issue 2(2020)
• Page Start: 197
• Page End: 203
• Publication Date: 2020-01-17
• Subjects: Callicarpa kwangtungensis -- Verbenacase -- norneolignans -- nitric oxide -- RAW264.7 cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1525374
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new norneolignans, (7 S, 8 R )-3-methoxy-3′, 4, 9-trihydroxy-4′, 7-epoxy-8, 3′-neolignane-1′-carboxylic acid (1 ) and (7 R, 8 R )-3-methoxyl-4, 9-dihydroxy-3′:7, 4′:8-diepoxyneolignan-1′-carboxylic acid methyl ester (2 ) were isolated from Callicarpa kwangtungensis, together with ten known compounds, genistin (3 ), daidzin (4 ), silybin A (5 ), isosilybin A (6 ), isosilybin B (7 ), p-hydroxybenzaldehyde (8 ), syringic acid (9 ), lanceolatin A (10 ), icariside C5 (11 ), and (3 S, 6 E, 10 R )-10- β -D-glucopyranosyloxy-3, 11-dihydroxy-3, 7, 11-trimethyldodeca-1, 6-diene (12 ). Compounds 1 and 2 were evaluated for their effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide induced RAW264.7 cells. Compounds 1 and 2 exhibited inhibitory activity with IC50 values of 31.45 ± 0.38 and 40.72 ± 0.54 μM, respectively. Abstract :