Why do we need to regulate autophagy (and how can we do it)? A cartoon depiction. Issue 10 (3rd October 2018)

• Record Type: Journal Article
• Authors: Klionsky, Daniel J.
• Is Part Of: Autophagy. Volume 14:Issue 10(2018)
• Page Start: 1661
• Page End: 1664
• Publication Date: 2018-10-03
• Subjects: Autophagosome -- frequency -- macroautophagy -- number -- regulation -- size; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1511218
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: In a recent issue of this journal I attempted to explain the purpose of macroautophagy/autophagy to a non-specialist audience through the use of cartoons. In the present article, I am continuing this approach by considering the topic of autophagy regulation—why does the cell need to modulate the autophagic response, and what are the basic morphological mechanisms that can be used to attain different levels of autophagy activity?