Impact of bariatric surgery on neural food processing and cognition: an fMRI study. Issue 9 (28th September 2018)

• Record Type: Journal Article
• Authors: Schulze, Marcel; Sörös, Peter; Vogel, Wolfgang; Münte, Thomas F; Müller, Helge H O; Philipsen, Alexandra
• Is Part Of: BMJ open. Volume 8:Issue 9(2018)
• Publication Date: 2018-09-28
• Subjects: neurobiology -- magnetic resonance imaging -- neurophysiology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-022375
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: The Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of the neural correlates associated with food-processing and cognitive performance in patients with morbid obesity before and after RYGB relative to lean controls. Methods and analysis: This study is a pre–post case–control experiment. Using functional MRI, the neural responses to food stimuli and a working memory task will be compared between 25 patients with obesity, pre and post RYGB, and a matched, lean control group. Resting state fMRI will be measured to investigate functional brain connectivity. Baseline measurements for both groups will take place 4 weeks prior to RYGB and 12 months after RYGB. The effects of RYGB on peptide tyrosine tyrosine and glucagon-like polypeptide-1 will also be determined. Ethics and dissemination: The project has received ethical approval by the local medical ethics committee of the Carl-von-Ossietzky University of Oldenburg, Germany (registration: 2017-073). Results will be published in a peer-reviewed journal as original research and on international conferences. Trial registration number: DRKS00012495; Pre-results.