News and views on EMT Fra-1 controls EMT in mammary epithelial cells. (3rd May 2016)

• Record Type: Journal Article
• Authors: Bakiri, Latifa; Wagner, Erwin F.
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 3(2016)
• Publication Date: 2016-05-03
• Subjects: EpH4 -- Zeb1 -- Zeb2 -- E-cadherin -- tumorigenesis -- metastasis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.4161/23723556.2014.990307
• Languages: English
• ISSNs: 2372-3556

Abstract

Abstract : Epithelial-to-mesenchymal transition (EMT), a process critical for breast cancer cell dissemination, engages the Fos-related antigen 1 (Fra-1) transcription factor. Molecular and cellular analyses revealed an evolutionary conservation of Fra-1 functions in EMT of mouse and human mammary cells, establishing a solid basis for preclinical studies in genetically engineered mouse models.