Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn's disease. Issue 3 (29th May 2019)

• Record Type: Journal Article
• Authors: Sokol, Harry; Brot, Loic; Stefanescu, Carmen; Auzolle, Claire; Barnich, Nicolas; Buisson, Anthony; Fumery, Mathurin; Pariente, Benjamin; Le Bourhis, Lionel; Treton, Xavier; Nancey, Stéphane; Allez, Matthieu; Seksik, Philippe
• Other Names: author non-byline.; Cattan Pierre author non-byline.; Chirica Mircea author non-byline.; Munoz-Bongrand Nicolas author non-byline.; Corte Hélène author non-byline.; Gornet Jean-Marc author non-byline.; Baudry Clotilde author non-byline.; Lourenco Nelson author non-byline.; Maillet Mariane author non-byline.; Tran-Minh My-Linh author non-byline.; Nisard Andrée author non-byline.; Beaugerie Laurent author non-byline.; Bourrier Anne author non-byline.; Nion-Larmurier Isabelle author non-byline.; Landman Cecilia author non-byline.; Rajca Sylvie author non-byline.; Quevrain Elodie author non-byline.; Brot Loic author non-byline.; Chafai Najim author non-byline.; Lefevre Jeremie author non-byline.; Tiret Emmanuel author non-byline.; Svreck Magali author non-byline.; Hoyau-Idrissi Nadia author non-byline.; Flejou Jean François author non-byline.; Guedj Nathalie author non-byline.; Panis Yves author non-byline.; Magiorri Leon author non-byline.; Feron Mariane author non-byline.; Bouhnik Yoram author non-byline.; Corcos Olivier author non-byline.; Dray Xavier author non-byline.; Chaput Ulrika author non-byline.; Marteau Philippe author non-byline.; Bommelaer Gilles author non-byline.; Goutte Marion author non-byline.; Vazeille Emilie author non-byline.; Rodrigues Michael author non-byline.; Sauvanet Pierre author non-byline.; Coban Dilek author non-byline.; Desreumaux Pierre author non-byline.; Nachury Maria author non-byline.; Sommeville Coralie author non-byline.; Dupas Jean-Louis author non-byline.; Brazier Franck author non-byline.; Chatelain Denis author non-byline.; Attencourt Christophe author non-byline.; Sabbagh Charles author non-byline.; Leconte Martine author non-byline.; Boschetti Gilles author non-byline.; Flourié Bernard author non-byline.; François Yves author non-byline.; Cotte Eddy author non-byline.; Charlois Anne-Laure author non-byline.; Falgon Peggy author non-byline.; Moussata Driffa author non-byline.; Chauvenet Marion author non-byline.; Boyer Sarah author non-byline.; Hafjisavvas Hélène author non-byline.; Hebuterne Xavier author non-byline.; Filippi Jérome author non-byline.; Hofmann Paul author non-byline.; Lechardeur Jessica author non-byline.; Bezault Madeleine author non-byline.; Margalef Carole author non-byline.; Detre Patricia author non-byline.;
• Is Part Of: Gut. Volume 69:Issue 3(2020)
• Page Start: 462
• Page End: 472
• Publication Date: 2019-05-29
• Subjects: colonic microflora -- Crohn's disease; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gutjnl-2019-318719
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Objective: Following ileal resection for Crohn's disease (CD), recurrence is very frequent. Although several clinical risk factors of recurrence have been identified, predicting relapse remains challenging. Performing an ileocolonoscopy within the first year after surgery is currently recommended to assess endoscopic recurrence and to adjust the treatment. We took advantage of a large prospective multicentric cohort to investigate the role of the ileal mucosa-associated microbiota in postoperative endoscopic recurrence. Patients and methods: Ileal mucosa-associated microbiota was analysed by 16S sequencing at the time of surgery and/or of endoscopic evaluation in 201 patients (288 samples in total) prospectively recruited in France. Results: Ileal mucosa-associated microbiota exhibits profound changes following surgery in CD. Compared with non-recurrence setting, endoscopic recurrence is associated with strong changes in ileal mucosa-associated microbiota that are highly reminiscent of those observed generally in ileal CD compared with healthy subjects with a reduction in alpha diversity, an increase in several members of the Proteobacteria phylum and a decrease in several members of the Lachnospiraceae and the Ruminococcaceae families within the Firmicutes phylum. At the time of surgery, we identified several bacterial taxa associated with endoscopic recurrence and that can better predict relapse than usual clinical risk factors. Conclusion: Surgery has an important impact on ileal mucosa-associated microbiota. Postoperative endoscopic recurrence is associated with changes in microbiota composition and alpha diversity. The gut microbiota has the potential to predict postoperative evolution and recurrence.