Antifungal activity of phenolic compounds identified in flowers from North Eastern Portugal against Candida species. (February 2014)

• Record Type: Journal Article
• Authors: Alves, Carlos Tiago; Ferreira, Isabel CFR; Barros, Lillian; Silva, Sónia; Azeredo, Joana; Henriques, Mariana
• Is Part Of: Future microbiology. Volume 9:Number 2(2014:Feb.)
• Page Start: 139
• Page End: 146
• Publication Date: 2014-02
• Subjects: antifungal effect -- biofilms -- Candida species -- medicinal flowers -- phenolic compounds; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb.13.147
• Languages: English
• ISSNs: 1746-0913

Abstract

ABSTRACT: : Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of North Eastern Portugal, against Candida planktonic and biofilm cells.Materials & methods: The MICs were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification of colony-forming units.Results: MIC values demonstrated that gallic acid presented the highest effect against all Candida species. Catechin showed a similar effect against Candida albicans American Type Culture Collection (ATCC) 90028 cells. In addition, gallic acid and quercetin had demonstrated only a minimal effect against Candida species biofilms.Conclusion: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used; still, catechin showed a similar effect against C. albicans ATCC 90028 and Candida glabrata ATCC 2001 cells. In addition, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.