562 Can 2D speckle tracking echocardiography have an additional impact on prediction of hospitalizations due to heart failure decompensation in patients with ischemic left ventricular systolic dysfunction. (17th January 2020)

• Record Type: Journal Article
• Authors: Szwoch, M; Kaufmann, D; Raczak, G; Danilowicz-Szymanowicz, L
• Is Part Of: European heart journal. Volume 21(2020)Supplement 1
• Publication Date: 2020-01-17
• Subjects: Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.10754
• DOI: 10.1093/ehjci/jez319.292
• Languages: English
• ISSNs: 2047-2404

Abstract

Abstract: Funding Acknowledgements: NA Background: Despite advancements in medical therapy and device-based treatment, heart failure (HF) continues to impose enormous burden for both patients and health care system worldwide. Hospitalizations due to HF decompensation is well-known cause of mortality. Objectives were to verify whether 2D speckle tracking echocardiography (2D STE) provides independently of other well-known clinical and echocardiographic parameters, information on the risk of HF decompensation in patients with left ventricular systolic dysfunction of ischemic origin. Materials and Methods: In 193 stable ischemic HF patients with left ventricular ejection fraction (LVEF) ≤ 50%, global longitudinal strain (GLS), as well as other echocardiographic (GE VIVID E9, EchoPAC v201) and well-known clinical parameters were analyzed. During 34 (14 – 71) months of follow-up, 58 patients were hospitalized due to HF decompensation (EVENT). Results: LVEF, GLS, diastolic function and well-known clinical parameters (age, renal function, hemoglobin, brain natriuretic peptide level, history of diabetes, diuretic treatment and the absence of beta-blockers), as well as cut-off values of these parameters identified in ROC analysis were significantly associated with the risk of EVENT in univariate Cox hazard regression analysis (Table). GLS value of -9.4% was the most accurate predictor of EVENT (AUC 80.7% [CI 57.6 – 100%]), whereas other parameters were characterized by lower discriminatory power. In multivariate Cox analyses GLS of -9.4% was still a significant predictor of the EVENT. Conclusions: 2D STE can provide additional information, independently of other well-known clinical and echocardiographic parameters, on the risk of HF decompensation in the patients with left ventricular systolic dysfunction of ischemic origin. GLS value worse than -9.4% can identify the patients with higher risk of this EVENT.