A review on ZnO-based electrical biosensors for cardiac biomarker detection. (7th June 2017)

• Record Type: Journal Article
• Authors: Shanmugam, Nandhinee R; Muthukumar, Sriram; Prasad, Shalini
• Is Part Of: Future science OA. Volume 3:Number 4(2017)
• Publication Date: 2017-06-07
• Subjects: biomarker -- biosensor -- disease diagnosis -- electrical detection -- POC -- point-of-care -- zinc oxide; Medicine -- Periodicals; Biotechnology -- Periodicals; 610
• DOI: 10.4155/fsoa-2017-0006
• Languages: English
• ISSNs: 2056-5623

Abstract

Over the past few decades zinc oxide (ZnO)-based thin films and nanostructures have shown unprecedented performance in a wide range of applications. In particular, owing to high isoelectric point, biocompatibility and other multifunctional characteristics, ZnO has extensively been studied as a transduction material for biosensor development. The fascinating properties of ZnO help retain biological activity of the immobilized biomolecule and help in achieving enhanced sensing performance. As a consequence of recent advancements in this multidisciplinary field, diagnostic biosensors are expanding beyond traditional clinical labs to point-of-care and home settings. Label-free electrical detection of biomarkers has been demonstrated using ZnO-sensing platforms. In this review we highlight the characteristics of ZnO that enable realization of its use in development of point-of-care biosensors toward disease diagnosis, in particular cardiovascular diseases. Lay abstract: The goal of this review is to discuss the features of ZnO in enhancing the sensitivity and selectivity of biomarker detection toward the development of point-of-care diagnostic devices. Basic biosensor design features and fabrication of ZnO nanostructures, strategies for surface modifications and its application toward disease diagnosis are discussed.