The ameliorative effects of vinpocetine on apoptosis and HSP-70 expression in testicular torsion in rats. (17th February 2017)

• Record Type: Journal Article
• Authors: Sönmez, MF; Ozdemir, Ş; Guzel, M; Kaymak, E
• Is Part Of: Biotechnic & histochemistry. Volume 92:Number 2(2017)
• Page Start: 92
• Page End: 99
• Publication Date: 2017-02-17
• Subjects: antioxidant -- apoptosis -- HSP-70 -- rat -- testicular torsion -- vinpocetine; Histochemistry -- Periodicals; Stains and staining (Microscopy) -- Periodicals; Biotechnology -- Periodicals; 572
• DOI: 10.1080/10520295.2016.1259499
• Languages: English
• ISSNs: 1052-0295

Abstract

Abstract: Vinpocetine is a potent antioxidant and free radical scavenger. We investigated the effects of vinpocetine on torsion/detorsion (T/D) induced testicular damage, HSP-70 expression and germ cell apoptosis in rats. Sixty Wistar albino adult male rats were divided into five groups of 12. The groups comprised a control group, a sham treated group, a T/D group, a vinpocetine treated group, and a T/D plus vinpocetine treated group. The left testis of each rat was subjected to unilateral torsion followed by detorsion after 2 h. Vinpocetine was administered intraperitoneally immediately and for 10 days following detorsion. At the end of the study, the rats were sacrificed and their testes removed and processed. HSP-70 expression, apoptosis and histopathological damage scores were determined for each group. Testicular T/D caused significant increases in apoptosis and HSP-70 expression, and a significant decrease in Johnsen's testicular biopsy scores and mean seminiferous tubule diameter. Vinpocetine ameliorated testicular histopathology and HSP-70 expression in the T/D + vinpocetine group. Consequently, vinpocetine may prevent testicular injury following testicular torsion owing to its antioxidant effects.