Metabolic behavior and prognostic value of early and end of treatment 18F-FDG PET/CT in adult Burkitt's lymphoma: the role of Deauville and IHP criteria. Issue 2 (28th January 2019)

• Record Type: Journal Article
• Authors: Albano, Domenico; Bosio, Giovanni; Re, Alessandro; Pagani, Chiara; Giubbini, Raffaele; Bertagna, Francesco
• Is Part Of: Leukemia & lymphoma. Volume 60:Issue 2(2019)
• Page Start: 326
• Page End: 333
• Publication Date: 2019-01-28
• Subjects: PET/CT -- Burkitt's lymphoma -- Deauville criteria -- International Harmonization Project; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2018.1482541
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Burkitt's lymphoma is a lymphoma with unclear metabolic behavior at 18F-FDG-PET/CT and no validated criteria in treatment evaluation and prediction of outcome exist. Sixty-five patients were retrospectively included: all underwent baseline 18F-FDG-PET/CT, 56 interim PET/CT (iPET/CT) and 54 end of treatment PET/CT (eotPET/CT) after chemotherapy. Interim and eotPET/CT results were visually interpreted according to the criteria of the IHP and Deauville-five-point-scale. Results were correlated with PFS and OS to assess and to compare the predictive value of iPET and eotPET according to each criterion. All baseline PET/CT showed increased 18F-FDG uptake in nodal and extranodal lesions. The median PFS and OS were 44.6 and 48.2 months with 3-year and 5-year PFS of 76% and 62% and 3-year and 5-year OS of 71% and 57%, respectively. EotPET/CT results using DC and IHP significantly correlate with OS and PFS; while iPET/CT did not correlated with OS and PFS.