C-MYC partners with BPTF in human cancer. (3rd May 2016)

• Record Type: Journal Article
• Authors: Richart, Laia; Real, Francisco X.; Sanchez-Arevalo Lobo, Victor Javier
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 3(2016)
• Publication Date: 2016-05-03
• Subjects: BPTF -- c-MYC -- chromatin remodeling -- transcription; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2016.1152346
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: The c-MYC oncogene is deregulated in virtually all human tumors and therefore constitutes an attractive therapeutic target. We found that the chromatin remodeler BPTF is a c-MYC interactor required for c-MYC chromatin recruitment and transcriptional activity. Moreover, inhibition of BPTF delays tumor development both in vitro and in vivo and its levels positively correlate with c-MYC signatures in human tumors. We propose BPTF as a therapeutic target in c-MYC-addicted tumors.