Design, synthesis, and antimicrobial activity of fluorophore 1, 2, 3-triazoles linked nicotinonitrile derivatives. Issue 16 (18th August 2019)

• Record Type: Journal Article
• Authors: El-Sayed, Hassan A.; Abdel Hamid, Atef M.; Mohammed, Samar M.; Moustafa, Ahmed H.
• Is Part Of: Synthetic communications. Volume 49:Issue 16(2019)
• Page Start: 2096
• Page End: 2105
• Publication Date: 2019-08-18
• Subjects: Antimicrobial activity -- click reaction -- fluorescence properties -- 2-oxonicotinonitrile -- 1, 2, 3-triazole; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2019.1616760
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: The synthesis and investigation of fluorescence and antimicrobial properties of a new series of 1, 2, 3-triazoles were described. Acetylenes 4a–c were resulted via alkylation of 2-oxonicotinonitriles 3a–c with propargyl bromide in base medium. [2 + 3] cycloaddition of acetylenes 4a–c with ethyl 2-azidoacetate, p -acetylphenylazide, and p -tolylsulfonylazide in the presence of Cu(I) afforded 1, 2, 3-triazoles 5a–c, 7a–c, and 9, respectively (via click reaction). The triazoles 5a–c were subjected to saponification process to give the acids 6a–c . The fluorescence and antimicrobial properties of triazoles 5a–c, 7a–c, and 9 were investigated and significant results were obtained. GRAPHICAL ABSTRACT: