Narciclasine-4-O-β-D-xylopyranoside, a new narciclasine glycoside from Zephyranthes minuta. Issue 2 (17th January 2020)

• Record Type: Journal Article
• Authors: Katoch, Deepali; Kumar, Dharmesh; Padwad, Yogendra S; Singh, Bikram; Sharma, Upendra
• Is Part Of: Natural product research. Volume 34:Issue 2(2020)
• Page Start: 233
• Page End: 240
• Publication Date: 2020-01-17
• Subjects: Zephyranthes minuta -- Amaryllidaceae alkaloid -- Narciclasine-4-O-β-D-xylopyranoside -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1527836
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new narciclasine glycoside, narciclasine-4- O - β -D-xylopyranoside (1 ) was characterised along with four known alkaloids pancratistatin (2 ), 1- O -(3-hydroxybutyryl) pancratistatin (3 ), vittatine (4 ), 9- O -demethylgalanthine (5 ) from Zephyranthes minuta . Their structures were established on the basis of spectroscopic data analysis. The in vitro cytotoxic study of extract, fractions and isolated compounds against two human cancer cell lines (KB and SiHa) indicated the potential activity of extract and n -butanol fraction due to presence of active alkaloids pancratistatin, 1- O -(3-hydroxybutyryl) pancratistatin, lycorine and haemanthamine. Graphical Abstract: