Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe. Issue 4 (16th February 2020)

• Record Type: Journal Article
• Authors: Abdou, Randa; Shabana, Samah; Rateb, Mostafa E.
• Is Part Of: Natural product research. Volume 34:Issue 4(2020)
• Page Start: 503
• Page End: 510
• Publication Date: 2020-02-16
• Subjects: Terezine E -- endophyte -- cytotoxic -- antimicrobial; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1489393
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe . Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains. Graphical Abstract: