Relations between kinetic parameters of different column models for liquid chromatography applying core-shell particles. Issue 1 (20th January 2019)

• Record Type: Journal Article
• Authors: Qamar, Shamsul; Bashir, Seemab; Perveen, Sadia; Seidel-Morgenstern, Andreas
• Is Part Of: Journal of liquid chromatography & related technologies. Volume 42:Issue 1/2(2019)
• Page Start: 16
• Page End: 30
• Publication Date: 2019-01-20
• Subjects: Core-shell particles -- Liquid chromatography -- mathematical models -- moment analysis -- matching relations -- semi-analytical solutions; Liquid chromatography -- Periodicals; Chromatographic analysis -- Periodicals; Separation (Technology) -- Periodicals; Biotechnology -- Periodicals; Chromatography, Liquid -- Periodicals; 543.8405
• DOI: 10.1080/10826076.2019.1570522
• Languages: English
• ISSNs: 1082-6076

Abstract

Abstract: This article presents analytical solutions of the general rate model (GRM), the lumped kinetic model (LKM), and the simpler equilibrium dispersive model (EDM) for core-shell particles and linear adsorption isotherms. The solutions in the Laplace domain are applied to derive analytical expressions for the temporal moments of these models. The results provide relations between the model specific kinetic parameters by matching one or more of the temporal moments. Several case studies are considered for illustration. The results show that simpler models are in many cases as good as the most detailed GRM if their kinetic parameters fulfill the matching relations. Thus, it is possible to reliably predict elution profiles using the simpler models. The derived analytical expressions can also be utilized to efficiently estimate model parameters from experimentally observed elution profiles to further optimize core-shell particles and to identify suitable column sizes and operating conditions. Graphical Abstract: