A new [7.7]paracyclophane from Vietnamese marine snail Planaxis sulcatus (Born, 1780). Issue 2 (17th January 2020)

• Record Type: Journal Article
• Authors: Thanh, Nguyen Van; Thao, Nguyen Phuong; Phong, Nguyen Viet; Cuong, Nguyen Xuan; Nam, Nguyen Hoai; Minh, Chau Van
• Is Part Of: Natural product research. Volume 34:Issue 2(2020)
• Page Start: 261
• Page End: 268
• Publication Date: 2020-01-17
• Subjects: Planaxis sulcatus -- Planaxidae -- [7.7]paracyclophane -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1528586
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new [7.7]paracyclophane (1 ), together with eight known compounds (2 –9 ), were isolated from a MeOH extract of the sea snail Planaxis sulcatus (Born, 1780). Their structures were elucidated by HR-ESI-MS and NMR techniques as well as comparison with those reported in literatures. The absolute configuration of metabolite 1 was determined using ECD spectroscopy. Among nine compounds, 1 exhibited significant cytotoxicity toward all eight cancer cells tested with IC50 values between 1.81 and 3.80 µg/mL.