Dysfunctional HDL: the journey from savior to slayer. (February 2014)

• Record Type: Journal Article
• Authors: Serban, Corina; Muntean, Danina; Mikhailids, Dimitri P; Toth, Peter P; Banach, Maciej
• Is Part Of: Clinical lipidology. Volume 9:Number 1(2014)
• Page Start: 49
• Page End: 59
• Publication Date: 2014-02
• Subjects: atherosclerosis -- biomarker -- dysfunctional HDL -- HDL -- lipid disorder; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/clp.13.83
• Languages: English
• ISSNs: 1758-4299

Abstract

HDL has many functions such as reverse cholesterol transport, anti-inflammation and antioxidation. Different clinical conditions associated with inflammation, oxidation, advanced glycation and protein carbamylation can alter the functionality of HDL, converting normal HDL into dysfunctional HDL, which is no longer cardioprotective. Dysfunctional HDL leads to the impairment of reverse cholesterol transport and might exhibit proinflammatory, pro-oxidant, prothrombotic and proapoptotic properties, all responsible for the subsequent endothelial dysfunction. This review addresses the current knowledge regarding the loss-of-function and gain-of-dysfunction responsible for the proatherosclerotic properties of HDL in several pathological conditions associated with systemic inflammation.