Post-operative complications due to salvage total laryngectomy for recurrent laryngeal cancer after radiotherapy – a multicentre retrospective study. (1st February 2020)

• Record Type: Journal Article
• Authors: Okamoto, Isaku; Matsuki, Takashi; Sato, Hiroki; Kondo, Takahito; Fushimi, Chihiro; Okada, Takuro; Miura, Kouki; Yamashita, Taku; Omura, Go; Tsukahara, Kiyoaki
• Is Part Of: Acta oto-laryngologica. Volume 140:Number 2(2020)
• Page Start: 170
• Page End: 174
• Publication Date: 2020-02-01
• Subjects: Radiotherapy -- chemoradiotherapy -- salvage total laryngectomy -- pharyngocutaneous fistula -- pharyngeal interposition graft -- pectoralis major myocutaneous flap; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2019.1699251
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Few studies have demonstrated the utility of pharyngeal interposition graft (PIG) applying pectoralis major myocutaneous flap (PMMCF) by comparing pharyngocutaneous fistula (PCF) rates. Objective: The objective of this retrospective study was to clarify the utility of PIG applying PMMCF in reducing post-operative complications due to salvage total laryngectomy (STL). Material and methods: STL was performed in 59 patients with recurrent laryngeal cancer after radiotherapy, comprising 37 non-PMMCF patients and 22 PMMCF patients. The primary endpoint was PCF rate. Comparisons were made between two groups: a group with simple closure not using PMMCF (non-PMMCF group), and the other with PMMCF used in a PIG (PMMCF group). Results: PCF occurred in 15 of the 59 subjects (25.4%), including 13 of the 37 patients in the non-PMMCF group (35.1%) and 2 of the 22 patients in the PMMCF group (9.1%). PCF rate was significantly lower in the PMMCF group than in the non-PMMCF group ( p = .033). Conclusions and significance: We demonstrated that PIG applying PMMCF significantly reduced the PCF rate due to STL. In the future, surgeons need to conduct research focused on additional innovations to reduce post-operative complications as much as possible.