Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging. (1st January 2018)

• Record Type: Journal Article
• Authors: Lee, Jung Eun; Kim, Myung Goo; Jang, Yeon Lim; Lee, Min Sang; Kim, Nak Won; Yin, Yue; Lee, Jong Han; Lim, Su Yeon; Park, Ji Won; Kim, Jaeyun; Lee, Doo Sung; Kim, Sun Hwa; Jeong, Ji Hoon
• Is Part Of: Drug delivery. Volume 25:Number 1(2018)
• Page Start: 1570
• Page End: 1578
• Publication Date: 2018-01-01
• Subjects: Drug dissolution -- oil-free formulation -- human serum albumin -- self-assembled nanoparticle -- systemic cancer therapy; Drug delivery systems -- Periodicals; Drug targeting -- Periodicals; 615.05
• DOI: 10.1080/10717544.2018.1489430
• Languages: English
• ISSNs: 1071-7544

Abstract

Abstract: Paclitaxel (PTX) is used as a major antitumor agent for the treatment of recurrent and metastatic breast cancer. For the clinical application of PTX, it needs to be dissolved in an oil/detergent-based solvent due to its poor solubility in an aqueous medium. However, the formulation often causes undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose-dependent antitumor effect. Herein, we introduce a facile and oil-free method to prepare albumin-based PTX nanoparticles for efficient systemic cancer therapy using a conjugate of human serum albumin (HSA) and poly(ethyleneglycol) (PEG). PTX were efficiently incorporated in the self-assembled HSA-PEG nanoparticles (HSA-PEG/PTX) using a simple film casting and re-hydration procedure without additional processes such as application of high pressure/shear or chemical crosslinking. The spherical HSA-PEG nanoparticle with a hydrodynamic diameter of ca. 280 nm mediates efficient cellular delivery, leading to comparable or even higher cytotoxicity in various breast cancer cells than that of the commercially available Abraxane ® . When systemically administered in a mouse xenograft model for human breast cancer, the HSA-PEG-based nanoparticle formulation exhibited an extended systemic circulation for more than 96 h and enhanced intratumoral accumulation, resulting in a remarkable anticancer effect and prolonged survival of the animals.