Effect of early use of low-dose aspirin therapy on late-onset preeclampsia. (3rd July 2019)

• Record Type: Journal Article
• Authors: Lan, Patrick G.; Gillin, Adrian G.; Pelosi, Marilena; Tooher, Jane; Sandager, Puk; Hyett, Jon
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 32:Number 13(2019)
• Page Start: 2137
• Page End: 2142
• Publication Date: 2019-07-03
• Subjects: Aspirin -- late-onset pre-eclampsia -- clinical severity; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2018.1427718
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: Low-dose aspirin (LDA) therapy has been found to be effective in preventing the development of early-onset preeclampsia. However, its effect on late-onset preeclampsia has not been described. Our study was aimed at determining if LDA therapy prescribed from early in pregnancy modified the severity of late-onset preeclampsia. Materials and methods: A retrospective analysis of all women who were screened for early-onset preeclampsia at 11–13 +6 weeks' gestation between April 2012 and October 2014 at our institution, and who subsequently developed late-onset preeclampsia. The treatment group consisted of women who were prescribed LDA therapy from early in pregnancy as a result of the screening. The control group consisted of women who did not receive LDA therapy. Results: The aspirin group was associated with earlier delivery at 38.0 (37.5–38.5) weeks' gestation versus 39.0 (38.7–39.4) weeks' gestation for the nonaspirin group ( p < .01). The aspirin group was also associated with lower absolute birth weight 2851 (2646–3055) versus 3215 (3068–3362) grams in the nonaspirin group ( p < .01). However, when normalised for gestational age at delivery, the proportion of foetuses that were small for gestation age (< 10th centile) were not significantly different between the two groups [28% in aspirin group versus 23% in nonaspirin group; p = .62]. No other significant difference was noted. Conclusions: There was no difference in the clinical severity of late-onset preeclampsia between women screened as high risk for early-onset preeclampsia and subsequently prescribed LDA during their pregnancy, compared to women found to be at low risk and not prescribed LDA.