Association between gestational diabetes and biomarkers: a role in diagnosis. (19th May 2018)

• Record Type: Journal Article
• Authors: Adam, Sumaiya; Pheiffer, Carmen; Dias, Stephanie; Rheeder, Paul
• Is Part Of: Biomarkers. Volume 23:Number 4(2018)
• Page Start: 386
• Page End: 391
• Publication Date: 2018-05-19
• Subjects: Biomarkers -- gestational diabetes -- adiponectin -- insulin; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2018.1432690
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Background: We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. Methods: In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. Results: Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier ( p = 0.04) and had more clinical risk factors ( p = 0.008). We found a significant difference in fasting insulin ( p < 0.001), adiponectin ( p = 0.046), HOMA ( p < 0.001) and QUICKI ( p < 0.001). HOMA (AUROC = 0.82) or QUICKI (AUROC = 0.82) improved the ability of risk factors to identify women at high risk of GDM. Conclusions : Insulin sensitivity markers are promising tools to identify women at high risk of GDM.