What is next generation sequencing?. Issue 6 (28th August 2013)

• Record Type: Journal Article
• Authors: Behjati, Sam; Tarpey, Patrick S
• Is Part Of: Archives of disease in childhood. Volume 98:Issue 6(2013)
• Page Start: 236
• Page End: 238
• Publication Date: 2013-08-28
• Subjects: Technology -- Basic Science; Pediatrics -- Practice -- Periodicals; Children -- Diseases -- Treatment -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2013-304340
• Languages: English
• ISSNs: 1743-0585

Abstract

Abstract : Next generation sequencing (NGS), massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has revolutionised genomic research. Using NGS an entire human genome can be sequenced within a single day. In contrast, the previous Sanger sequencing technology, used to decipher the human genome, required over a decade to deliver the final draft. Although in genome research NGS has mostly superseded conventional Sanger sequencing, it has not yet translated into routine clinical practice. The aim of this article is to review the potential applications of NGS in paediatrics.