Novel Core–Shell Polyamine Phosphate Nanoparticles Self‐Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time (Small 35/2021). Issue 35 (2nd September 2021)

• Record Type: Journal Article
• Authors: Andreozzi, Patrizia; Simó, Cristina; Moretti, Paolo; Porcel, Joaquin Martinez; Lüdtke, Tanja Ursula; Ramirez, Maria de los Angeles; Tamberi, Lorenza; Marradi, Marco; Amenitsch, Heinz; Llop, Jordi; Ortore, Maria Grazia; Moya, Sergio Enrique
• Is Part Of: Small. Volume 17:Issue 35(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-02
• Subjects: biological fate -- polyamine phosphate nanoparticles -- polyethylene glycol -- small angle X‐ray scattering -- self assembly; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202170182
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Polyamine Phosphate Nanoparticles In article number 2102211, Sergio Enrique Moya and co‐workers present supramolecular polyamine phosphate nanoparticles (PANs) assembled from polyamines modified with polyethylene glycol (PEG) that vary size and charge depending on the number of PEG molecules per polyamine. PEGylated PANs with 10 PEG chains per polyamine display a core shell structure and show a longer circulation in vivo and reduced toxicological endpoints in vitro through the screening of positive charges by the PEG shell.