ASSA13-14-25 The Difference of Blood Pressure and Left Ventricular Hypertrophy Among Spontaneously Hypertensive Rats with Treatment of Metoprolol, Amlodipine and Benazepril in Cold Stress. (29th April 2013)

• Record Type: Journal Article
• Authors: Hai, Su; Chuanfu, Sun; Yunkai, Wang; Jiwei, Wang; Qiang, Xiong; Dezi, Hong; Liu, Huihua
• Is Part Of: Heart. Volume 99(2013)Supplement 1
• Page Start: A66
• Page End: A66
• Publication Date: 2013-04-29
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-303992.202
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To evaluate the effect of 3 anti-hypertensive drugs on blood pressure (BP) and left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR) with cold stress. Methods: Forty male SHR were randomly divided into five groups (n = 8):control group (SHR-C), cold stress control group (C-SHR-C, in 5 ± 2°C walk-in chamber for 4 hours per day); and 3 treated cold groups:metoprolol (C-SHR-M, 50mg/kg.d), amlodipine (C-SHR-A, 2.5mg/kg.d), and benazepril (C-SHR-B, 10mg/kg.d). In the 6 week period, SBP, body weight (BW) and heart rate (HR) were measured once a week. At the sixth week, left ventricle weight (LVW) and LV weight index (LVWI), the concentrations of Endothelin-1 (ET-1) and nitric oxide (NO) in blood and myocardial, myocardial mRNA expression of ET-A receptor (ETAR mRNA) were gained. Results: One week cold stress increased significantly SBP in SHR. The SBPs in the 3 intervention groups were lower than in C-SHR-C from the 3rd week, especially in amlodipine group. Their LVWI, ET-I levels in blood and myocardium and the expression of ETAR mRNA were lower and the NO were higher, but the best effect was seen in the amlodipine group. Conclusions: Cold stress can induce significant SBP and LVWI increase in SHR, and ET system activation is a responsive factor for LVH. On the usually recommended doses, amlodipine offered better effect on SBP control and LVH prevention than metoprolol and benazepril.