ASSA13-14-28 Relationship Between Day-By-Day Variability of Self-Measured Blood Pressure at Home and Carotid Artery Atherosclerosis, Brachial Flow-Mediated Dilation, and Endothelin-1 in Normotension and Mild-Moderate Hypertensive Subjects. (29th April 2013)

• Record Type: Journal Article
• Authors: Zhendong, Liu; Fanghong, Lu; Yingxin, Zhao; Yutao, Diao; Hua, Zhang; Shangwen, Sun; Hongbin, Song; Zaiwen, Qi
• Is Part Of: Heart. Volume 99(2013)Supplement 1
• Page Start: A66
• Page End: A67
• Publication Date: 2013-04-29
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-303992.205
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To investigate the relationship between variability of self-measured blood pressure at home (HBPV) and carotid artery atherosclerosis and endothelial function in normotensive and mild-moderate hypertensive individuals. Methods: Seven consecutive days HBP monitoring, carotid artery ultrasound, brachial artery flow-mediated dilation (FMD) were performed in 314 volunteers. HBPV was assessed by the standard deviations of the daily BP average of the last 6 consecutive days. Plasma endothelin-1 level was tested using ELISA. Results: The tendency of systolic HBPV significantly increased from normotension to moderate hypertension group. Systolic HBPV was closely correlated with carotid intima-media thickness (IMT) ( r = 0.569, p < 0.001), stiffness parameter β ( r = 0.447, p < 0.001), FMD ( r = –0.636, p < 0.001), and endothelin-1 ( r = 0.649, p < 0.001). Diastolic HBPV was correlated with carotid IMT, stiffness parameter β, FMD, and endothelin-1, but the strength of the correlation was weaker than systolic HBPV (All p < 0.001). After adjusted all covariants, only systolic HBPV was always significantly associated with carotid IMT, stiffness parameter β, FMD, and endothelin-1. Conclusions: HBPV was increasing with BP level elevated. It significantly associated with carotid artery atherosclerosis and endothelial function in normotensive and mild-moderate hypertensive subjects.