ASSA13-01-6 Association of C-Reactive Protein Gene T-757C Polymorphism in the Promoter Region with Unstable Angina Pectoris. (29th April 2013)

• Record Type: Journal Article
• Authors: He, Guoping; Meng, Qi
• Is Part Of: Heart. Volume 99(2013)Supplement 1
• Page Start: A2
• Page End: A2
• Publication Date: 2013-04-29
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-303992.006
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To investigate the impossible association between C-reactive protein (CRP) gene T-757C polymorphism in the promoter region and unstable angina pectoris (UAP) in a Chinese Han population of Suwan region. Methods: This study was conducted with a case-control design including 165 patients with UAP (UAP group) and 282 control subjects who were free from coronary artery disease through coherence checks (control group). The T-757C polymorphism in CRP gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Compared with the control group, the frequencies of TT, TC and CC genotype were not significantly different in UAP group (P > 0.05). The prevalence of T allele was 77.6% and 79.1% (P > 0.05), respectively in the UAP group and control group. Multivariate logistic regression analysis indicates that there was no significant correlation between CRP gene T-757C polymorphism and UAP (P > 0.05). Conclusions: Our findings suggest that the T-757C polymorphism in CRP gene may be not the risk for UAP among the Chinese Han population of Suwan region.