ASSA13-16-6 The Increased Circulatory RAS Activity Can Be Inhibited by Statins. (29th April 2013)

• Record Type: Journal Article
• Authors: Hai, Su; Weitong, Hu; Qiang, Peng; Dezhi, Hong; Jianyong, Ma; Qing, Yang; Xiaoshu, Cheng
• Is Part Of: Heart. Volume 99(2013)Supplement 1
• Page Start: A77
• Page End: A78
• Publication Date: 2013-04-29
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2013-303992.240
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To investigate the profile of circulatory renin-angiotensin system (RAS) activity in hypercholesterolemia (HC) patients treated with statins. Methods: This study included 18 primary HC patients and 18 sex-and age-matched healthy adults. Total cholesterol (TC), triglyceride (TG), LDL-C and blood glucose, angiotensin-converting enzyme (ACE) activity and angiotensin II (AngII) levels were measured at baseline. These parameters were measured again at 4 and 8 weeks after statin treatment in HC group respectively. Results: At baseline, the TC, TG and LDL-C, as well as ACE activity and AngII level, were significantly higher in HC group. On the baseline data of 36 participates, significant positive correlations existed between ACE activity and TC(r = 0.54) or LDL-C(r = 0.51), and between AngII level and TC(r = 0.34) or LDL-C(r = 0.27). In HC patients, 8 weeks statin treatment significantly decreased TC, LDL-C, as well as Ang II (35.46 ± 14.49 vs 71.10 ± 20.47 pg/ml, P < 0.05) levels and ACE activity (108.9 ± 51.9vs 180.1 ± 71.3 U/L, P < 0.05), meanwhile, positive correlations between RAS activity and TC or LDL-C levels measured before and after treatment were seen in HC patients. Conclusions: Serum cholesterol-lowering with statins is associated with decreasing circulatory RAS activity in hypercholesterolemia patients.