Line‐field confocal optical coherence tomography of xanthogranuloma: Correlation with vertical and horizontal histopathology. (10th June 2021)

• Record Type: Journal Article
• Authors: Lacarrubba, Francesco; Verzì, Anna Elisa; Puglisi, Davide Francesco; Broggi, Giuseppe; Caltabiano, Rosario; Micali, Giuseppe
• Is Part Of: Journal of cutaneous pathology. Volume 48:Number 9(2021)
• Page Start: 1208
• Page End: 1211
• Publication Date: 2021-06-10
• Subjects: foamy histiocytes -- histopathology -- line‐field confocal optical coherence tomography -- Touton cells -- xanthogranuloma; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.14067
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Line‐field confocal optical coherence tomography (LC‐OCT) is a new noninvasive technique for a real‐time, vertical, and horizontal imaging of the skin at cellular resolution. A 47‐year‐old female presented with a 6‐month history of an asymptomatic yellowish papule. LC‐OCT evaluation was able to show the diagnostic microscopic features of xanthogranuloma and showed an excellent correlation with vertical and horizontal histopathological sections by revealing enlarged dermal papillae containing multiple, bright roundish giant cells, corresponding to foamy histiocytes, and giant cells characterized by a dark center surrounded by a highly hyper‐refractile peripheral ring, corresponding to Touton cells. LC‐OCT may represent a valid, noninvasive alternative to histopathological examination in clinically atypical cases of xanthogranuloma.