Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain. Issue 16 (22nd July 2021)

• Record Type: Journal Article
• Authors: Osawa, Shigehito; Kitanishi, Kenichi; Kiuchi, Maho; Shimonaka, Motoyuki; Otsuka, Hidenori
• Is Part Of: Macromolecular rapid communications. Volume 42:Issue 16(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-22
• Subjects: copper complexes -- dipicolylamine -- Fenton‐like reaction -- methacrylate polymers; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.202100274
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract: Copper complexes act as catalysts for redox reactions to generate reactive oxygen species that destroy biomolecules and, therefore, are utilized to design drugs including antitumor and antibacterial medicines. Especially, catalytic reaction for hydrogen peroxide decomposition is important because it includes the process for generating highly toxic hydroxyl radical, i.e., Fenton‐like reaction. Considering that multicoppers/hydrogen peroxide species are the important intermediates for the redox reaction, herein a polymer having copper complexes in the side chains is designed to facilitate the formation of the intermediates by building locally concentrated state of the copper complexes. The polymer increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species' generation, eventually leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of catalysts on polymers toward drug design with low amounts of transition metals. Abstract : Installing copper complexes into polymer side chains increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species' generation, leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of metal‐based catalysts on polymers toward drug design with low amounts of transition metals.