Electronic characteristics of BRCA1 mutations in DNA. Issue 8 (9th July 2021)

• Record Type: Journal Article
• Authors: He, Lijun; Zhang, Jinsha; He, Chengyun; Zhao, Boyang; Xie, Zhiyang; Chen, Weizhong; Sonawane, Mahadev R.; Patil, Sunil R.
• Is Part Of: Biopolymers. Volume 112:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-09
• Subjects: breast cancer 1 -- conductance -- density of states -- mutation -- transmission; Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.23465
• Languages: English
• ISSNs: 0006-3525

Abstract

Abstract: The efficient and low‐cost way for gene mutation detection and identification are conducive for the detection of disease. Here, we report the electronic characteristics of the gene of breast cancer 1 in four common mutation types: duplication, single nucleotide variant, deletion, and indel. The electronic characteristics are investigated by the combination of density functional theory and non‐equilibrium Green's function formulation with decoherence. The magnitude of conductance of these DNA molecules and mutational changes are found to be detectable experimentally. In this study, we also find the significant mutation type dependent on the change of conductance. Hence these mutations are expected to be identifiable. We find deletion type mutation shows the largest change in relative conductance (~97%), whereas the indel mutation shows the smallest change in relative conductance (~27%). Therefore, this work presents a possibility of electronic detection and identification of mutations in DNA, which could be an efficient method as compared to the conventional methods. Abstract :