Chemotherapy-related cognitive impairment (CRCI) among early-stage breast cancer survivors in Malaysia. Issue 5 (28th May 2021)

• Record Type: Journal Article
• Authors: Syed Alwi, Syarifah Maisarah; Narayanan, Vairavan; Mohd Taib, Nur Aishah; Che Din, Normah
• Is Part Of: Journal of clinical and experimental neuropsychology. Volume 43:Issue 5(2021)
• Page Start: 534
• Page End: 545
• Publication Date: 2021-05-28
• Subjects: Breast cancer survivors -- cognition -- cognitive impairment -- chemotherapy -- neuropsychological testing; Neuropsychology -- Periodicals; Psychophysiology -- Periodicals; Neurosciences -- Periodicals; Psychophysiology -- Periodicals; Societies, Medical -- Periodicals; 616.89
• DOI: 10.1080/13803395.2021.1945539
• Languages: English
• ISSNs: 1380-3395

Abstract

ABSTRACT: Introduction : Breast cancer survivors frequently develop cognitive impairment following chemotherapy which can significantly hamper their well-being, ability to function independently, and overall quality of life. Evidence of cognitive functioning in breast cancer survivors from lower and middle-income countries remains scarce. We examined the prevalence of cognitive impairment among Malaysian multiethnic early-stage breast cancer survivors one to three years post-chemotherapy. Methods: This cross-sectional study included 160 breast cancer survivors from the University Malaya Medical Center (UMMC). The cognitive assessments used included the Montreal Cognitive Assessment (MoCA-BM), the Rey Auditory and Verbal Learning Test (RAVLT-BM), and the digit span and arithmetic of the Working Memory Index (WMI) of Wechsler Adult Intelligence Scale-IV (WAIS-IV). Data were analyzed using independent sample t -tests and Pearson's correlation. Results: Our breast cancer survivors demonstrated poor performances in MoCA-BM (31.9%) RAVLT-BM, recall (53.8%), and WMI of WAIS-IV (51.3%) with 30.6% of them performed poorly in all three cognitive tests administered. There were no significant mean group differences in cognitive performances between <24 months after chemotherapy and ≥24 months after chemotherapy. Conclusions: A high proportion of breast cancer survivors exhibited poor performances in the cognitive assessments. Cognitive rehabilitation programmes tailored to the needs of these survivors should be incorporated into cancer care management.