Anti-inflammatory and hemostatic effects of Linaria reflexa Desf. Issue 16 (12th August 2021)

• Record Type: Journal Article
• Authors: Cheriet, Thamere; Hanfer, Mourad; Mancini, Ines; Benelhadj, Samiha; Laouas, Nour Essabah; Ameddah, Souad; Menad, Ahmed; Seghiri, Ramdane
• Is Part Of: Natural product research. Volume 35:Issue 16(2021)
• Page Start: 2778
• Page End: 2783
• Publication Date: 2021-08-12
• Subjects: flavones -- acids -- anti-inflammatory -- hemostatic -- Linaria reflexa; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1663516
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The work presented here was aimed to investigate the in vivo anti-inflammatory and in vitro hemostatic activities of Linaria reflexa extract and to establish the relationship between its bioactivity and chemical composition. Twenty-three secondary metabolites were identified, most of them are good anti-inflammatory agents, in line with data by carrageenin-induced rat paw edema assays of the n -butanol extract showing high anti-inflammatory inhibition (63.90%) of edema swelling in the rat paw at the dose 200 mg/kg after 4 h. Furthermore, both extent of inflammatory response and tissue injury were prevented keeping the levels of rate myeloperoxidase (60.16%) and of malondialdehyde, which is the final product of lipid peroxidation generated by free radicals (58.58%). The same extract showed also a remarkable hemostatic effect established by measuring the coagulation time of decalcified plasma (45 s), related to its flavonoid glycosides content. Graphical Abstract: