Jatrophacine, a 4, 5-seco-rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas. Issue 16 (12th August 2021)

• Record Type: Journal Article
• Authors: Hu, Yang; Zhao, Huimin; Yang, Aiping; Lv, Qi; Ding, Ning; Lu, Tu-Lin; Hu, Lihong; Wang, Xiachang
• Is Part Of: Natural product research. Volume 35:Issue 16(2021)
• Page Start: 2748
• Page End: 2752
• Publication Date: 2021-08-12
• Subjects: Jatropha curcas -- Euphorbiaceae -- Rhamnofolane diterpenoid -- Jatrophacine -- Anti-inflammatory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1660656
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new diterpenoid named jatrophacine (1 ), with an unusual 4, 5- seco - rhamnofolane skeleton, was isolated from the roots of Jatropha curcas, together with eleven known diterpenoids. The structure of the new compound was elucidated through a detailed analysis of its 1 D- and 2 D-NMR spectra. The X-ray structure of jatrophol (2 ) is also presented. Anti-inflammatory activity with LPS-induced RAW 264.7 macrophages revealed that compound 1 strongly inhibited the production of nitric oxide (IC50 = 0.53 μM). GRAPHICAL ABSTRACT: