Cytotoxicity of isoflavones from Millettia dura. Issue 16 (12th August 2021)

• Record Type: Journal Article
• Authors: Buyinza, Daniel; Yang, Li Jun; Derese, Solomon; Ndakala, Albert; Coghi, Paolo; Heydenreich, Matthias; Wong, Vincent Kam Wai; Möller, Heiko M.; Yenesew, Abiy
• Is Part Of: Natural product research. Volume 35:Issue 16(2021)
• Page Start: 2744
• Page End: 2747
• Publication Date: 2021-08-12
• Subjects: Millettia dura -- Leguminosae -- isoflavone -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1660335
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM). Graphical Abstract: