3, 4-seco-lupane triterpene derivatives with cytotoxic activities from the leaves of Eleutherococcus sessiliflorus. Issue 16 (12th August 2021)

• Record Type: Journal Article
• Authors: Zhang, Danfeng; Chen, Chen; Zhao, Yan; Gao, Yugang; Cai, Enbo; Zhu, Hongyan
• Is Part Of: Natural product research. Volume 35:Issue 16(2021)
• Page Start: 2633
• Page End: 2639
• Publication Date: 2021-08-12
• Subjects: Eleutherococcus sessiliflorus -- 3, 4-seco-lupane triterpene -- sessiligenin -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1656622
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new 3, 4- seco -lupane triterpene, named sessiligenin (1 ), along with four known 3, 4- seco -lupane triterpene derivatives (chiisanogenin 2, chiisanoside 3, divaroside 4, and sessiliside-A1 5 ) were isolated from the ethanol extract of the leaves of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.Y. Hu by silica gel column chromatography, and their structures were determined by spectroscopic data. Furthermore, all these compounds were tested for their cytotoxicities against cancer cell lines HepG2, B16-F10, Lewis and YAC-1, as well as normal cell lines NCTC1469 and HL-7702, and significant cytotoxicities had been found for this new compound (sessiligenin 1 ) which exhibited much lower cytotoxicities against normal cell lines NCTC1469 and HL-7702. It was deduced that the reduce of glycosyl from the structures of these 3, 4- seco -lupane triterpenoids enhanced the cytotoxicities. Furthermore, with the complete removal of glycosyl group and the 11-hydroxyl and 3-carboxyl formed by the opening of the lactone ring, the cytotoxicity increased significantly. GRAPHICAL ABSTRACT: