Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029. Issue 16 (12th August 2021)

• Record Type: Journal Article
• Authors: Song, Zhijun; Liu, Yu; Gao, Jieyu; Hu, Jiansen; He, Hongtao; Dai, Shengwang; Wang, Luoqiang; Dai, Huanqin; Zhang, Lixin; Song, Fuhang
• Is Part Of: Natural product research. Volume 35:Issue 16(2021)
• Page Start: 2647
• Page End: 2654
• Publication Date: 2021-08-12
• Subjects: Marine-derived Fungus -- Aspergillus fumigatus -- Mycobacterium bovis bacillus Calmette–Guérin; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1660331
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: During the systematic screening of bioactive compounds from our marine natural product library, crude extract of the marine-derived fungus strain Aspergillus fumigatus MF029 exhibited moderate bioactivities against Bacillus subtilis, S taphylococcus aureus, methicillin-resistant S. aureus, and Mycobacterium bovis bacillus Calmette–Guérin (BCG). Further chemical investigation resulted in the identification of two new compounds, chaetominine A (1 ) and sphingofungin I (2 ), together with four known compounds, emodin (3 ), chaetominine (4 ), sphingofungin D (5 ) and trypacidin (6 ). Trypacidin displayed potential antitubercular activity with MIC value of 1.25 μg/mL. Graphical Abstract: