Association between Dietary Intake of Folate and the Risks of Multiple Cancers in Chinese Population: A Dose-Response Meta-Analysis of Observational Studies. (18th August 2021)

• Record Type: Journal Article
• Authors: Chen, Yulin; Zhan, Jian; Wang, Ying; Chen, Shiyu
• Is Part Of: Nutrition and cancer. Volume 73:Number 9(2021)
• Page Start: 1644
• Page End: 1656
• Publication Date: 2021-08-18
• Subjects: Cancer -- Periodicals; Nutrition -- Periodicals; Cancer; Nutrition; Periodicals; 616.9940654
• DOI: 10.1080/01635581.2020.1817512
• Languages: English
• ISSNs: 0163-5581

Abstract

Abstract: Background and objective: A lot of existing studies had revealed the associations between dietary folate intake and certain cancers, and generated inconsistent results. In addition, evidence on the association among Chinese population has not been systematically assessed. Therefore, we conducted a meta-analysis on this topic. Methods: PubMed and Embase were searched up to March 20, 2020 for potential studies. Pooled relative risks (RR) and dose-response analysis were used to examine dietary folate intake and cancers risks among Chinese population. Results: Seven cohort studies and 9 case-control studies that involved 561538 participants and 10073 cancer events were included. The summary RR of cancer events for the highest vs. lowest category was 0.73 (0.61, 0.88). Dose-response analysis revealed that those maintaining 250 μg daily intake of dietary folate had the lowest risk of cancers events among Chinese. Conclusion: Our findings indicate the inverse association between dietary folate intake and risk of cancers events, the association is especially clear in women.