Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives. Issue 67 (2nd August 2021)

• Record Type: Journal Article
• Authors: Deau, Emmanuel; Le Foll, Alexandra; Fouache, Clémence; Corrot, Emilie; Bailly, Laetitia; Levacher, Vincent; Marchand, Pierric; Querniard, Florian; Bischoff, Laurent; Brière, Jean-François
• Is Part Of: Chemical communications. Volume 57:Issue 67(2021)
• Page Start: 8348
• Page End: 8351
• Publication Date: 2021-08-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc03477d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An expeditious synthesis of taurine derivatives though a key unprecedented organocatalyzed enantioselective sulfa-Michael addition of bisulfite onto nitrostyrenes. Abstract : An unprecedented enantioselective conjugate addition reaction of sodium bisulfite to various nitrostyrenes occurred upon the influence of a bifunctional amino-thiourea organocatalyst; a strategy that opens a straightforward route to unprotected chiral taurine derivatives thanks to the reduction of the obtained β-nitroethanesulfonic acids into the corresponding amino derivatives.