40 Quantification of Aortic Regurgitation Following Transcatheter Aortic Valve Implantation (TAVI): A CMR Study of Two Prosthesis Designs. (3rd June 2016)

• Record Type: Journal Article
• Authors: Musa, Tarique Al; Uddin, Akhlaque; Dobson, Laura E; Swoboda, Peter P; Garg, Pankaj; Fent, Graham J; Foley, James RJ; Malkin, Christopher J; Plein, Sven; Blackman, Daniel J; Greenwood, John P
• Is Part Of: Heart. Volume 102(2016)Supplement 6
• Page Start: A28
• Page End: A29
• Publication Date: 2016-06-03
• Subjects: TAVI -- Cardiac MRI -- Aortic Regurgitation; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2016-309890.40
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Background: Transcatheter aortic valve implantation is an established therapeutic option for patients with severe symptomatic aortic stenosis unsuitable for surgery. CMR has a lower intra-observer and inter-observer variability than echocardiography in the assessment of aortic regurgitation (AR), offering full volumetric quantitation independent of the number or eccentricity of regurgitant jets. Moderate AR following TAVI is an independent predictor of mortality in the postoperative period and has prompted development of novel bioprostheses designed to facilitate precise deployment and minimise paravalvular regurgitation (Figure 1 ). Aim: To compare the degree of early post-procedure aortic regurgitation following implantation of the Medtronic CoreValve and Boston Scientific Lotus Valve systems in patients treated for severe symptomatic aortic stenosis. Methods: All patients underwent an identical 1.5T CMR scan (Intera, Phillips Healthcare, Best, Netherlands) post-procedure prior to discharge. Through-plane phase contrast velocity encoded imaging was performed perpendicular to the aortic valve jet at a level above the aortic prosthesis. Aortic flow was subsequently quantified offline (QFlow version 7.2, Medis Medical Imaging Systems, Leiden, The Netherlands) and regurgitant fraction (%) derived. AR was defined as regurgitant fraction of none/trivial ≤ 5%, mild 6 – 15%, moderate 16 – 25%, moderate-severe 26 – 48%, and severe > 48% The invasive AR index derived at the time of TAVI was also recorded ([(Diastolic BP-LVEDP)/Systolic BP] x100). Results: 18 Medtronic CoreValve patients (age 79.6 ± 6.3 years, 67% male, EuroSCORE II 4.59 ± 3.59%) and 24 Boston Lotus TAVI patients (age 78.6 ± 8.7years, 54% male, EuroSCORE II 4.07 ± 3.37%) were studied at a median interval of 6 days following implantation. The residual peak aortic pressure gradient observed following Boston Lotus implantation was higher than that following Medtronic CoreValve (25.8 ± 12.1 vs.15.0 ± 5.5mmHg, p = 0.001). The absolute regurgitant fraction was significantly lower following Boston Lotus implantation than following Medtronic CoreValve (Lotus: 4.0 ± 3.5% vs. CoreValve: 11.7 ± 7.2%, p = 0.001). The classification of AR severity is summarised in Figure 2 . Overall, 39% of patients with CoreValve had moderate AR compared to no reported cases in the Lotus group. There was a negative correlation between invasive AR index and regurgitant fraction from CMR imaging (Spearman's coefficient − 0.4, p = 0.016). Conclusions: CMR directly quantifies AR following TAVI and there is agreement with invasive AR measurements. There was significantly less aortic regurgitation in the immediate post-implant period using the Boston Lotus valve compared with the Medtronic CoreValve. However the residual peak pressure gradient was lower with the Medtronic CoreValve. Further work is required to assess the longer term differences in AR and whether this translates into a mortality benefit.