141 Cardcardiovascular Manifestations of Turner Syndrome in a Tertiary Centre Population. (6th June 2015)

• Record Type: Journal Article
• Authors: Hamilton-Baillie, Agnes; Toogood, Andrew; Clift, Paul
• Is Part Of: Heart. Volume 101(2015)Supplement 4
• Page Start: A81
• Page End: A81
• Publication Date: 2015-06-06
• Subjects: Turner Syndrome -- Cardiovascular abnormality -- Cardiovascular imaging; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/heartjnl-2015-308066.141
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Introduction: Turner Syndrome is associated with increased risk of congenital heart defects. We sought to detail cardiovascular abnormalities in a tertiary centre Turner Syndrome clinic. Method: A comprehensive list was compiled of 67 Turner Syndrome patients under QEHB care. MRI and echocardiographic scans were reviewed for evidence of cardiovascular anomalies. Case notes were reviewed for previous interventions, use of oestrogen, and evidence of hypertension. The use of ACE inhibitors (ACEi)/angiotensin II receptor antagonists (A2A) was recorded. Results: 57/67 (85%) of patients had undergone either MRI or echocardiographic evaluation. The following abnormalities were found: bicuspid aortic valve (BAV) 25/67 (37%), coarctation 16/67 (24%), aortic dilatation 10/67 (15%), arterial aberrancy 10/67 (15%), systemic venous anomaly 6/67 (9%), and pulmonary venous anomaly 6/67 (9%). Interventions (surgery or catheter based) occurred in 18/67 patients (27%), 13/67 (19%) had BP >140/90 and 19/67 (28%) were on either ACEi or A2A. 39 patients had indexed MRI measurements available of which 11/39 (28%) has an enlarged aorta defined by indexed aortic dimension >2.0 cm/m 2, with 2/39 (5%) with an indexed aortic dimension >2.5 cm/m 2 . Conclusions: Cardiovascular abnormalities (including bicuspid aorta, coarctation and increased aortic size – all risk factors for dissection) are common in Turner Syndrome patients. Patients with Turner Syndrome require regular cardiovascular imaging to identify and monitor these abnormalities.