Self‐Powered Controllable Transdermal Drug Delivery System. (25th June 2021)

• Record Type: Journal Article
• Authors: Yang, Yuan; Xu, Lingling; Jiang, Dongjie; Chen, Bo Zhi; Luo, Ruizeng; Liu, Zhuo; Qu, Xuecheng; Wang, Chan; Shan, Yizhu; Cui, Yong; Zheng, Hui; Wang, Zhiwei; Wang, Zhong Lin; Guo, Xin Dong; Li, Zhou
• Is Part Of: Advanced functional materials. Volume 31:Number 36(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-06-25
• Subjects: conductive microneedles -- drug delivery -- on‐demand -- psoriasis -- self‐powered; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202104092
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Traditional topical ointment applied on the skin surface has poor drug penetration due to the thickening of the stratum corneum for psoriasis. Microneedles (MNs) provide a desirable opportunity to promote drug penetration. However, the common MNs are difficult to meet the requirement of on‐demand drug delivery. In this study, a smart electrical responsive MNs is fabricated by introducing conductive material of polypyrrole (PPy). Further, a self‐powered controllable transdermal drug delivery system (sc‐TDDS) based on piezoelectric nanogenerator (PENG) is developed. The sc‐TDDS can control drug release by collecting and converting mechanical energy into electrical energy. The sc‐TDDS can release 8.5 ng dexamethasone (Dex) subcutaneously per electrical stimulation. When treating psoriasis‐like skin disease with sc‐TDDS, the inflammatory skin returned to normal after 5 days, which is obviously better than treating with traditional Dex solution coating. This work provides a promising approach of on‐demand transdermal drug release for various disease treatment scenarios. Abstract : An integrated self‐powered transdermal drug delivery system based on a piezoelectric nanogenerator (PENG) and the conductive microneedle patch (MNP) is proposed. PENG can control the release of the drug from the MNP by converting mechanical energy into electrical energy. The system has the characteristics of being lightweight, painless, possessing on‐demand drug delivery, and high utilization rate, which present a good therapeutic effect on psoriasis‐like skin diseases.