Brønsted Acid Promoted N‐Dealkylation of N‐Alkyl(sulfon)amides. Issue 33 (6th September 2021)

• Record Type: Journal Article
• Authors: Gu, Linghui; Wang, Yang; Cheng, Zemin; Sun, Yanan; Gong, Xin; Li, Zheyu; Ma, Wenbo
• Is Part Of: ChemistrySelect. Volume 6:Issue 33(2021)
• Page Start: 8839
• Page End: 8842
• Publication Date: 2021-09-06
• Subjects: Brønsted Acid -- N-dealkylation -- N-alkyl(sulfon)amide -- Primary amides; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202101676
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A simple and efficient Brønsted‐acid‐promoted N ‐dealkylation of N ‐alkylamides and N ‐alkylsulfonamides has been developed. This strategy features an ample substrate scope with excellent chemical selectivity, affording primary (sulfon)amide derivatives in moderate to good yields without the need for transition‐metal catalysts. Abstract : A simple and efficient Brønsted‐acid‐promoted N ‐dealkylation of N ‐alkylamides and N ‐alkylsulfonamides has been developed. This strategy features an ample substrate scope with excellent chemical selectivity, affording primary (sulfon)amide derivatives in moderate to good yields without the need of transition‐metal catalysts