Sesquiterpenoids from Artemisia argyi and their NO production inhibitory activity in RAW264.7 cells. Issue 17 (19th August 2021)

• Record Type: Journal Article
• Authors: Xue, Gui-Min; Xue, Jin-Feng; Zhao, Chen-Guang; Zhao, Zhen-Zhu; Sun, Yan-Jun; Du, Kun; Li, Han-Wei; Feng, Wei-Sheng
• Is Part Of: Natural product research. Volume 35:Issue 17(2021)
• Page Start: 2887
• Page End: 2894
• Publication Date: 2021-08-19
• Subjects: Artemisia argyi -- sesquiterpenoid -- anti-inflammatory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1680665
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Investigation into the chemical diversity of Artemisia argyi led to the discovery of two new (1, 4 ) and four known (2-3, 5 -6 ) sesquiterpenoids. The new structures were determined via extensive spectroscopic data, including IR, UV, MS, and NMR, and the absolute configurations of these compounds were elucidated by calculated ECD method. All isolates were tested for their inhibitory activity against NO production in RAW 264.7 macrophages, and the isolated sesquiterpenoids exhibited NO production inhibitory activity with IC50 values ranging from 1.91 to 36.52 μM. Abstract : UF0001