Dissolution thermodynamics and preferential solvation of meloxicam in (acetonitrile + water) mixtures. (3rd September 2021)

• Record Type: Journal Article
• Authors: Tinjacá, Darío A.; Martínez, Fleming; Almanza, Ovidio A.; Jouyban, Abolghasem; Acree, William E.
• Is Part Of: Physics and chemistry of liquids. Volume 59:Number 5(2021)
• Page Start: 733
• Page End: 752
• Publication Date: 2021-09-03
• Subjects: Meloxicam -- {acetonitrile (1) + water (2)} mixtures -- cosolvency -- dissolution thermodynamics -- Jouyban-Acree model -- preferential solvation -- IKBI; Liquids -- Periodicals; 530.4205
• DOI: 10.1080/00319104.2020.1808658
• Languages: English
• ISSNs: 0031-9104

Abstract

ABSTRACT: Solubility of meloxicam in {acetonitrile + water} mixtures at five temperatures from 293.15 K to 313.15 K has been determined and correlated by means of the Jouyban-Acree model. By using the van't Hoff and Gibbs equations the respective apparent thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy, were calculated. Non-linear enthalpy–entropy relationship was observed in the plot of enthalpy vs . Gibbs energy exhibiting negative slope in the composition region 0.00 < x 1 < 0.20 and variant slopes in the other mixtures. Based on the inverse Kirkwood-Buff integrals it follows that meloxicam is preferentially solvated by water molecules in water-rich and acetonitrile-rich mixtures but preferentially solvated by acetonitrile molecules in mixtures 0.26 < x 1 < 0.60.