Acetylcholinesterase and α-glucosidase inhibitory compounds from Callicarpa maingayi. Issue 17 (19th August 2021)

• Record Type: Journal Article
• Authors: Ado, Muhammad A.; Maulidiani, M.; Ismail, Intan Safinar; Ghazali, Hasanah M.; Shaari, Khozirah; Abas, Faridah
• Is Part Of: Natural product research. Volume 35:Issue 17(2021)
• Page Start: 2992
• Page End: 2996
• Publication Date: 2021-08-19
• Subjects: Callicarpa maingayi -- α-glucosidase inhibitor -- triterpenoids -- acetylcholinesterase inhibitor; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1679138
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Phytochemical investigation on the soluble fractions of n -hexane and dichloromethane of methanolic leaves extract of the Callicarpa maingayi K. & G. led to the isolation of three triterpenoids [euscaphic acid (1 ), arjunic acid (2 ), and ursolic acid (3 )] together with two flavones [apigenin (4 ) and acacetin (5 )], two phytosterols [stigmasterol 3- O -β-glycopyranoside (6 ) and sitosterol 3- O -β-glycopyranoside (7 )], and a fatty acid [ n -hexacosanoic acid (8 )]. Six (6) compounds (1, 2, 3, 4, 5, and 8 ) are reported for the first time from this species. Their structures were elucidated and identified by extensive NMR techniques, GC-MS and comparison with the previously reported literature. Compound 3 was found to displayed good inhibition against acetylcholinesterase with an IC50 value of 21.5 ± 0.022 μM, while 1 and 2 exhibited pronounced α-glucosidase inhibitory activity with IC50 values of 22.4 ± 0.016 μM and 24.9 ± 0.012 μM, respectively. Abstract : UF0001