Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity. Issue 17 (19th August 2021)

• Record Type: Journal Article
• Authors: Vinh, Le Ba; Nguyet, Nguyen Thi Minh; Thanh, Chu Duc; Huong, Tran Thu; Tram, Le Huyen; Van Thong, Nguyen; Minh, Nguyen Hoang; Thao, Nguyen Phuong; Hwang, Inkyu; Yang, Seo Young; Kim, Young Ho
• Is Part Of: Natural product research. Volume 35:Issue 17(2021)
• Page Start: 2899
• Page End: 2904
• Publication Date: 2021-08-19
• Subjects: Hibiscus tiliaceus -- Malvaceae -- megastigmane -- antioxidant -- α-glucosidase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1672065
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Using various chromatographic techniques, a total of 15 compounds, including one novel megastigmane named tiliaceic acid A (1 ) and 14 known compounds, were isolated from the traditional medicinal Vietnamese mangrove Hibiscus tiliaceus . Their structures were confirmed based on spectroscopic experiments including, UV, 1 D- and 2 D-NMR, HR-ESI-MS, and ECD analysis. The antioxidant and α-glucosidase inhibitory activities of the isolated compounds from H. tiliaceus were evaluated for the first time. Compound 2 showed strong α-glucosidase inhibitory activity with an IC50 of 77.78 ± 1.00 μM compared with the positive control acarbose at 105.71 ± 2.29 μM. Graphical Abstract: UF0001