Organ-on-chip applications in drug discovery: an end user perspective. (27th August 2021)

• Record Type: Journal Article
• Authors: Clapp, Naomi; Amour, Augustin; Rowan, Wendy C.; Candarlioglu, Pelin L.
• Is Part Of: Biochemical Society transactions. Volume 49:Number 4(2021)
• Page Start: 1881
• Page End: 1890
• Publication Date: 2021-08-27
• Subjects: drug development -- drug discovery -- microfluidic models -- organ-on-a-chip; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20210840
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : Organ-on-chip (OoC) systems are in vitro microfluidic models that mimic the microstructures, functions and physiochemical environments of whole living organs more accurately than two-dimensional models. While still in their infancy, OoCs are expected to bring ground-breaking benefits to a myriad of applications, enabling more human-relevant candidate drug efficacy and toxicity studies, and providing greater insights into mechanisms of human disease. Here, we explore a selection of applications of OoC systems. The future directions and scope of implementing OoCs across the drug discovery process are also discussed.