Protein release from interpenetrating polymer network hydrogels triggered by endogenous biomarkers. (August 2021)

• Record Type: Journal Article
• Authors: Massana Roquero, D.; Bollella, P.; Smutok, O.; Katz, E.; Melman, A.
• Is Part Of: Materials today chemistry. Volume 21(2021)
• Publication Date: 2021-08
• Subjects: Hydrogel -- Interpenetrating network -- Alginate -- Biomolecule release -- Biomarkers; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2021.100514
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: A biocompatible drug delivery system with a high-sensitive stimuli-responsive behavior is reported. Calcium alginate hydrogels interpenetrated with polyvinyl alcohol–diboronate polymer network (IPN) effectively respond to the presence of hydrogen peroxide through oxidative degradation of boronate esters. The degradation of the IPN entails the reopening of the original alginate pores, resulting in a 5–9 times increase in release rates of encapsulated proteins with molecular masses ranging from 16.7 to 66 kDa. The release can be triggered by hydrogen peroxide concentrations as low as 50 μM in the bulk solution. Alternatively, hydrogen peroxide can also be generated inside the hydrogels by incorporation of oxidase enzymes in the presence of their substrates, such as lactate, glucose, or hypoxanthine, which can serve as biomarkers of certain physiological disorders. Graphical abstract: Image 1 Highlights: Novel signal-responsive material based on alginate hydrogel. Signal-triggered biomolecule release. Decreasing uncontrolled leakage of entrapped biomolecules. Interpenetrating polymer network used for blocking pores in the alginate hydrogel. Entrapped enzymes producing hydrogen peroxide in situ to stimulate biomolecule release.