Allium sativum mitigates oxidative damages induced by Microcystin-LR in heart and liver tissues of mice. (September 2021)

• Record Type: Journal Article
• Authors: Ait Abderrahim, Leila; Taibi, Khaled; Boussaid, Mohamed; Al-Shara, Baker; Ait Abderrahim, Nawel; Ait Abderrahim, Sabrina
• Is Part Of: Toxicon. Volume 200(2021)
• Page Start: 30
• Page End: 37
• Publication Date: 2021-09
• Subjects: Microcystin LR -- Oxidative stress -- Allium sativum -- Antioxidant -- Liver -- Heart; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2021.06.018
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: Microcystins (MCs) are hepatotoxic cyanotoxins implicated in several incidents of human and animal toxicity. Microcystin-(Lysine, Arginine) or MC-LR is the most toxic and encountered variant of MCs where oxidative stress plays a key role in its toxicity. This study investigated the oxidative damages induced in the liver and heart of Balb/C mice by an intraperitoneal injected acute dose of MC-LR. Thereafter, the potential protective effect of garlic ( Allium sativum ) extract supplementation against such damages was assessed through the evaluation of oxidative stress and cytotoxicity markers. Lipid peroxidation (LPO), carbonyl content (CC), glutathione content (GSH), alkaline phosphatase activity (ALP), lactate dehydrogenase (LDH) and sorbitol dehydrogenase (SDH) activities were measured. Results showed important oxidative damages in hepatic and cardiac cells of mice injected with the toxin. However, these damages have been significantly reduced in mice supplemented with garlic extract. Thus, this study demonstrated for the first time the effective use of garlic as an antioxidant agent against oxidative damages induced by MC-LR. As well, this study supports the use of garlic as a potential remedy against pathologies related to toxic agents. Highlights: Microcystin (Lysine, Arginine) injection induces severe oxidative damages in livers and heart of mice. Oral supplementation with garlic extract reduces significantly oxidative damages. Garlic constitutes a potential remedy for oxidative stress related ailments.