Powder X-ray diffraction of varenicline hydrogen tartrate Form B (Chantix®), (C13H14N3)(HC4H4O6). Issue 3 (September 2021)

• Record Type: Journal Article
• Authors: Kaduk, James A.; Gindhart, Amy M.; Blanton, Thomas N.
• Is Part Of: Powder diffraction. Volume 36:Issue 3(2021)
• Page Start: 202
• Page End: 204
• Publication Date: 2021-09
• Subjects: varenicline tartrate -- Chantix® -- Rietveld refinement -- density functional theory; Powder metallurgy -- Periodicals; Materials -- Analysis -- Periodicals; 620.1127
• DOI: 10.1017/S088571562100035X
• Languages: English
• ISSNs: 0885-7156

Abstract

Abstract : The crystal structure of varenicline hydrogen tartrate Form B (Chantix ® ) has been refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Varenicline hydrogen tartrate Form B crystallizes in space group P 21 21 21 (#19) with a = 7.07616(2), b = 7.78357(2), c = 29.86149(7) Å, V = 1644.706(6) Å 3, and Z = 4. The hydrogen bonds were identified and quantified. Hydrogen bonds link the cations and anions in zig-zag chains along the b -axis. The powder pattern has been submitted to ICDD ® for inclusion in the Powder Diffraction File™ (PDF ® ).